NNB Diet’s VasoRush™ is a peptide-bonded di-citrulline and di-arginine ingredient constructed for pumps. It absorbs quicker through PEPT-1 and drives extra cGMP per unit of nitric oxide, that means extra vasodilation, not simply extra NO.
The pre-workout pump class has spent 20 years fixated on nitric oxide. NNB Diet is lastly able to enter and reframe the dialog. VasoRush™ is NNB’s new peptide-bonded di-citrulline and di-arginine ingredient, constructed round a deceptively easy concept: nitric oxide is not truly the top objective. Vasodilation is.
There is a huge distinction right here, and NNB is pushing to re-educate the business and shoppers on what we’re actually in search of. Each pre-workout and pump components available on the market competes on how a lot nitric oxide it will probably produce. However paradoxically, nitric oxide ranges cannot even be reliably measured within the blood!
VasoRush™: NNB Diet’s Peptide Pump Ingredient That Pushes Vasodilation
VasoRush competes on how a lot vasodilation you get per unit of NO produced, which NNB argues is the extra essential variable. The mechanism behind that argument is cGMP (cyclic guanosine monophosphate), the downstream signaling molecule that tells blood vessels to dilate, and NNB’s in-house pre-clinical information reveals VasoRush producing greater, extra secure cGMP ranges than the present benchmark components in that class.
VasoRush additionally matches into what’s turn into a transparent strategic thread at NNB: peptide-bonded amino acids that outperform their free-form equivalents through the PEPT-1 transporter. Their DL185® Dileucine constructed that proof of idea for muscle protein synthesis, and VasoRush applies the identical supply logic to the NO pathway. This text introduces VasoRush and the mechanisms it enhances, however earlier than diving in, join PricePlow’s NNB Diet alerts in order that you do not miss new bulletins:
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What Is VasoRush?
VasoRush™ is a mix of di-citrulline and di-arginine in a 2:1 ratio, with every part delivered as a bonded dipeptide fairly than a free amino acid. Di-citrulline pairs two citrulline molecules collectively, and di-arginine does the identical with arginine. That structural change is what drives the absorption benefit and the downstream cGMP story NNB is constructing the ingredient round.
NNB Diet’s official spec sheet masking dosing, pre-clinical outcomes, and components stacking steerage for the brand new di-citrulline and di-arginine peptide ingredient.
The compounds happen naturally in peptide constructions present in meals and human biology, and NNB states they qualify as authorized dietary components with out requiring new regulatory registrations. The present studied dose is 5.2g per serving taken pre-workout, with one to 2 servings per day. NNB is actively testing smaller efficient doses, in order that quantity might lower as growth continues. Beverage and RTD functions are additionally being explored, pending solubility and pH stability testing on the present dose.
That is an ingredient constructed for vasodilation and velocity — getting higher pumps, quicker:
The PEPT-1 Benefit: Why Dipeptides Take in Sooner
The velocity benefit in VasoRush begins within the intestine. Free amino acids depend on amino acid transporters to cross the intestinal wall into the bloodstream. Dipeptides take a unique route: the PEPT-1 transporter (oligopeptide transporter 1), positioned within the intestinal brush border membrane, strikes di- and tripeptides throughout the mucosal barrier with out requiring prior hydrolysis to free amino acids.[1] PEPT-1 operates as a high-capacity electrogenic proton-coupled symporter, enabling uptake charges that typical amino acid transporters cannot match.[2]
NNB’s DL185® Dileucine established this mechanism’s business worth: two leucine molecules bonded collectively achieved 185% quicker absorption than free leucine through the identical transporter, with measurably higher downstream outcomes for muscle protein synthesis. VasoRush applies the identical logic to the NO pathway. Sooner absorption means arginine and citrulline substrates attain eNOS (endothelial nitric oxide synthase) sooner, which suggests earlier NO manufacturing. NNB’s pre-clinical information reveals that preliminary NO spike occurring inside half-hour.
The cGMP Story: Extra Vasodilation Per Unit of NO
That is VasoRush’s most original argument, and understanding it requires a fast stroll via the mechanism.
When eNOS produces nitric oxide within the endothelium, it diffuses into vascular easy muscle cells and prompts guanylate cyclase. That enzyme converts GTP into cGMP, which then reduces intracellular calcium, relaxes easy muscle, and produces vasodilation.[3] Nitric oxide sends the sign, however cGMP executes it. Extra cGMP per unit of NO means extra vasodilation per unit of NO. Much less cGMP means a whole lot of NO will get produced however does not totally translate into precise blood vessel dilation.
That is the hole VasoRush targets. In NNB’s in-house pre-clinical testing, VasoRush produced greater and extra secure plasma cGMP ranges over a 6-hour post-exercise window in comparison with a premium modified arginine ingredient. The comparator confirmed a pointy preliminary cGMP spike that dropped considerably across the 60-minute mark earlier than partially recovering, whereas VasoRush maintained elevated cGMP all through. The sensible upshot: extra constant vasodilation throughout longer periods, much less of a spike-and-crash sample between units, and diminished dependence on arginine availability or endothelial operate at any given second.
NNB Diet’s breakdown of why elevated cGMP issues greater than uncooked nitric oxide output, masking blood move, pump stability, aspect impact threat, and endurance output.
Analysis in animal fashions helps this pathway’s potential, exhibiting that mixed citrulline and arginine collectively produce quicker and extra marked will increase in plasma cGMP and NOx than both compound alone, with corresponding enhancements in blood move.[4] VasoRush’s peptide supply makes the case that getting these substrates into circulation quicker and extra reliably amplifies what the cGMP pathway can do with them.
Pre-Scientific Outcomes
NNB’s in-house pre-clinical testing measured VasoRush outcomes at 5 time factors post-exercise: 0, 30, 60, 120, and 360 minutes. It was paired towards one other premium third-party pre-workout ingredient. Key findings embody:
Fast NO elevation in plasma inside half-hour (NO rose from roughly 22 to 27 µmol/L)
Sustained elevated nitric oxide for as much as 6 hours (22 µmol/L on the 6-hour mark, considerably above management)
20.6% improve in cGMP vs. management
12.5% enchancment in operating endurance
10% improve in total nitric oxide ranges
These are NNB’s in-house pre-clinical findings, and impartial printed human trials have not been performed but. That is anticipated for a brand-new ingredient, and it means these numbers ought to be handled as early directional information fairly than established medical benchmarks. Further research are deliberate as VasoRush strikes towards business launch.
Why Free-Kind Falls Quick
Plasma NO and cGMP information tracked over 6 hours post-exercise, evaluating VasoRush towards management and a premium modified arginine ingredient.
The context for VasoRush’s argument is the blended observe document of free-form citrulline and arginine. Free-form arginine has a well-documented bioavailability downside: it is extensively catabolized by arginase within the gastrointestinal tract and liver earlier than it reaches circulation, which limits how a lot ever arrives at eNOS as a usable substrate.[3]
L-Citrulline (and citrulline malate) grew to become the class commonplace partly as a result of citrulline bypasses that first-pass downside. However a crucial evaluate of the citrulline malate literature discovered the ergogenic proof equivocal, with methodological inconsistencies, variable dosing, and high quality management points in business citrulline-to-malate ratios making it troublesome to attract agency conclusions about efficacy.[5] Extra not too long ago, a randomized managed trial on mixed free-form arginine and citrulline malate discovered no vital efficiency enhancements in cardio or anaerobic measures at typical doses, with solely a touch shorter time to peak energy in a single anaerobic take a look at as a notable consequence.[6]
VasoRush’s peptide supply addresses the foundation downside. Getting these substrates into circulation quicker and extra reliably is the core improve, earlier than the cGMP effectivity argument even enters the image.
Components Purposes and Stacking
VasoRush targets pre-workout and pump formulation, particularly in ready-to-mix powders. NNB recommends combining it with HydroPrime® to maximise the muscular pump throughout train, or pairing it with DL185® Dileucine when muscle progress can be a objective.
For manufacturers watching the RTD and practical beverage house, the potential is actual however contingent on fixing VasoRush’s solubility and pH stability at 5.2g. NNB’s PeptiClear™ idea demonstrated what peptide-delivery components can seem like in a transparent ready-to-drink format, and it raises the identical query for the pump class. Whether or not VasoRush is prepared for liquid functions at business launch continues to be being decided.
Pure. Potent. Exact. Utilized to the Pump Class
VasoRush is the most recent entry in NNB’s rising peptide platform. DL185® established the PEPT-1 proof of idea. PeptiClear™ prolonged proof that peptide supply could be finished within the RTD house. VasoRush now brings that very same logic to the pump and vasodilation class, which is the most important and best section within the pre-workout market.
The throughline throughout NNB’s work is in keeping with their core positioning: discover a mechanism the market hasn’t totally defined, engineer a molecule that delivers on that mechanism higher than commodity components, and let the differentiation do the business work. Their 2026 ingredient lineup, which additionally covers Icariin D2 and 4-Hydroxy-L-Isoleucine throughout sexual well being and glucose metabolism displays that very same method. VasoRush is their pump entry into that 2026 class.
Conclusion: VasoRush Is Coming to SupplySide World 2026
Shawn Wells and Dustin Elliott reveal NNB Diet’s Pure, Potent, Exact revolution at SupplySide World 2025, discussing precision fermentation, Pürest Creatine, OnSwitch beverage innovation, and the way forward for pharmaceutical-grade complement components on Episode #192 of the PricePlow Podcast
VasoRush is at the moment within the coming-soon stage, with a focused business debut at SupplySide World 2026. Dose optimization and supporting medical information are nonetheless in progress, however the core premise is already in place: a peptide-bonded di-citrulline and di-arginine ingredient that absorbs quicker through PEPT-1, produces greater and extra secure cGMP for extra environment friendly vasodilation, and provides formulators a genuinely completely different story to inform in a class that wants one.
For extra context on the considering behind NNB’s ingredient pipeline, try Episode #192 of the PricePlow Podcast, the place Shawn Wells and Dustin Elliott stroll via the Pure, Potent, Exact philosophy in depth (filmed at SupplySide world 2025).
Manufacturers seeking to discover VasoRush for upcoming formulation can attain NNB Diet via their web site at nnbnutrition.com. Subscribe under for continued PricePlow protection as VasoRush strikes towards launch:
