Antimicrobial resistance patterns and treatment outcomes of S. suis infections in Southeast Asia

Asserting a brand new article publication for Zoonoses journal. This examine was aimed toward conducting a scientific evaluate and meta-analysis of antimicrobial resistance patterns and remedy outcomes of S. suis infections in Southeast Asia, the place this zoonotic pathogen poses a serious public well being concern by way of consumption of uncooked or undercooked pork.

A scientific evaluate and meta-analysis have been performed by looking out 9 databases by way of December 2024. Research reporting antimicrobial resistance profiles of S. suis isolates or scientific outcomes amongst contaminated sufferers from Southeast Asian nations have been eligible for inclusion. Pooled estimates have been calculated with random-effects meta-analysis, and country-stratified analyses have been carried out to discover temporal resistance dynamics.

Ten eligible research from Thailand and Vietnam have been recognized, contributing 763 bacterial isolates and 618 sufferers. The pooled penicillin resistance was 2% (95% CI: 0-18%), and substantial heterogeneity was noticed throughout research (I2 = 68.8%). Nation-stratified evaluation revealed distinct temporal patterns: Thailand demonstrated non-linear resistance dynamics, whereas Vietnam maintained persistently low resistance all through the examine interval. The pooled mortality was 16% (95% CI: 11-22%) in people. Ceftriaxone, penicillin, and vancomycin remained efficient first-line remedy choices.

Though penicillin resistance stays low total, stories of intermediate resistance warrant continuous regional surveillance and strengthened antibiotic stewardship in pig farming. These findings ought to be interpreted cautiously, given the restricted eligible research and substantial heterogeneity.