Hardcore Nootropic Upgraded with Dual PEA, Dual-Caffeine Stack

Apollon Diet Extra time V6 is right here, and it does not pull punches. The rebuilt method runs a dual-PEA stack (ThinFen + NeuroPEA), 700mg theobromine, and ~500mg caffeine. Noopept’s gone. Begin at 4 caps, as a result of this one will get you wired.

L-Tyrosine – 2000mg

L-Tyrosine is a conditionally important amino acid and direct precursor to the catecholamine neurotransmitters dopamine and norepinephrine. After crossing the blood-brain barrier, it is transformed through tyrosine hydroxylase to L-DOPA, which then turns into dopamine and ultimately norepinephrine.[1][2]

The mechanism is demand-dependent: tyrosine solely enhances neurotransmitter synthesis in actively firing neurons.[1][2] Underneath sustained cognitive load, turnover of dopamine and norepinephrine accelerates till precursor availability turns into the limiting issue. Tyrosine supplementation retains that provide from working quick.

Analysis on tyrosine beneath cognitively demanding situations has proven enhancements in working reminiscence, inhibitory management, and cognitive flexibility, with the impact most constant when neurotransmitter methods are already beneath demand.[1][3] A scientific overview additionally recognized it as certainly one of few dietary supplements with significant help for cognitive output throughout sleep deprivation.[4] That context matches Extra time’s mission precisely. At 2000mg, the dose is in keeping with the 2g utilized in a number of optimistic cognition trials. Paired with 1200mg GPCgold™ masking the cholinergic facet and the dual-PEA stack triggering quick monoamine launch, tyrosine ensures dopamine and norepinephrine substrate stays forward of demand.

L-Alpha GPC (as GPCgold™) – 1200mg

Alpha-GPC (alpha-glycerylphosphorylcholine) is among the many most bioavailable choline sources, crossing the blood-brain barrier and changing to phosphatidylcholine to boost acetylcholine ranges at cholinergic synapses.[5] And it is a giant dose with a variety of scientific backing. Typically GPCgold is dosed at 50%, so we’re guessing the yield right here is 600mg precise alpha-GPC, which remains to be fairly giant.

A 2024 randomized crossover trial discovered each 315mg and 630mg (remaining yield) doses improved Stroop take a look at scores and completion occasions in wholesome males versus placebo,[6] providing a significant cognitive profit even under the total GPCgold™ dose used right here. Placebo-controlled analysis additionally discovered cholinergic supplementation could help upward shifts in motivation throughout sustained day by day duties.[7] One research famous TSH suppression at 500mg that will replicate upstream dopaminergic involvement, an angle that matches nicely alongside Extra time’s PEA-class compounds.[8]

On the bodily facet, acute 600mg dosing (what we possible have right here) augmented post-exercise progress hormone and peak bench press power versus placebo.[9] Pairing the 1200mg GPCgold™ with Huperzine A, which inhibits acetylcholinesterase, creates a two-pronged strategy to supporting wholesome cholinergic operate from separate angles. Caffeine’s adenosine receptor antagonism then provides a 3rd convergent pathway, pointing towards alertness and sustained psychological output.

At these doses, you’ll be able to inform Apollon is critical, as they usually are. However now we get into the PEA stack, which too many formulators appear to be forgetting about today:

ThinFen™ (Beta Phenylethylamine HCl) – 750mg

ThinFen™ is a branded beta-phenylethylamine (PEA) HCl, an endogenous hint amine synthesized from L-phenylalanine. Concentrated in nigrostriatal and mesolimbic circuits, PEA prompts TAAR1 (hint amine-associated receptor 1), a Gαs-coupled receptor that modulates dopamine and norepinephrine signaling in key motivational and mood-supporting pathways.[10]

Downstream, PEA promotes dopamine launch, inhibits dopamine transporter reuptake, and will increase tyrosine hydroxylase expression within the dorsal striatum, collectively driving the psychomotor focus and optimistic affective state that characterize ThinFen’s contribution right here.[11]

The sensible limitation of PEA is velocity: MAO-B degrades it in a short time, producing a short however concentrated impact window.[12] The 750mg dose delivers a high-amplitude pulse designed to register perceptibly with out concurrent MAO-B inhibition. The 2000mg L-Tyrosine on the high of this method supplies upstream dopamine synthesis help, pairing naturally with PEA’s release-and-reuptake mechanism. Cardio train additional will increase endogenous PEA manufacturing, boosting urinary phenylacetic acid (PEA’s main metabolite) by a median of 77% in wholesome topics.[13]

NeuroPEA, lined decrease, extends this with a structurally distinct PEA-class compound that holds longer, complementing ThinFen’s fast-onset burst.

Theobromine – 700mg

Theobromine is a methylxanthine alkaloid from cacao (Theobroma cacao) and the dominant compound by quantity in chocolate. Like caffeine, it antagonizes adenosine receptors, however with roughly 2-3x decrease affinity at A1 and significantly weaker exercise at A2A, producing a softer, predominantly peripheral profile somewhat than the CNS-forward stimulation caffeine delivers.[14] Its half-life runs 7 to 12 hours versus caffeine’s 2.5 to five, and peak plasma concentrations arrive 2 to three hours post-ingestion, extending whole protection after caffeine has leveled off.[15]

The 700mg dose is the true deal. Robik flagged this in Episode #211 of our Podcast, and there is a research to again the quantity: a placebo-controlled crossover trial examined precisely 700mg theobromine mixed with caffeine, discovering the mixture preserved alertness advantages whereas blunting caffeine’s pressor impact on blood stress.[16]

Apollon Diet reformulated Casanova with 10 clinical-dosed components for male vitality. New additions embody ashwagandha, shilajit, and spilanthes acmella. Yohimbine eliminated. Options 1500mg Nitrosigine, upgraded 30% icariin sexy goat weed, 500mg black ginger. Blood circulate, testosterone help, stress administration in a single method.

Most merchandise cap theobromine between 100mg and 200mg. Towards ~500mg whole caffeine, 700mg is a significant contributor, and it is a big a part of why Extra time’s stimulant profile carries the graceful, prolonged character that separates it from single-compound caffeine merchandise.

NeuroPEA™ Eria Jarensis Extract (N-Phenethyl Dimethylamine) – 600mg

NeuroPEA™ is the branded extract of N,N-Dimethylphenethylamine (DMPA) from Eria jarensis Ames, first recognized as a phenethylamine alkaloid supply in 1969.[17] DMPA is a hint amine that acts as a TAAR1 agonist, a receptor positioned to instantly affect dopamine and serotonin neuronal firing and launch.[10] In vitro, DMPA activated human TAAR1 as a partial agonist, reaching roughly two-thirds the height response phenethylamine produces at that receptor, with weaker further exercise at two ADRα1 adrenergic subtypes.[18] This implies we now have dopamine and serotonin modulation, however with a pure cap somewhat than the full-blast activation plain phenethylamine produces, plus extra cheap exercise at two adrenergic subtypes.

Not like plain beta-PEA, DMPA carries N,N-dimethyl teams on the amine nitrogen. Plain PEA is a selective substrate for MAO-B, which degrades it to phenylacetaldehyde and dimethylamine inside minutes. The dialkyl teams gradual that degradation and improve lipophilicity, supporting blood-brain barrier penetration.[19] Paired with ThinFen’s 750mg beta-PEA HCl, the 2 compounds produce complementary time profiles: quicker onset from the PEA spine, longer window from DMPA.

At 600mg, it is a very giant dose soar from the 125mg to 250mg vary early merchandise established.

Caffeine Anhydrous – 350mg (of ~500mg whole caffeine)

Prepare like a hooligan, sleep like a child. Apollon Diet From Nightfall Until Daybreak delivers 14 totally disclosed components together with 3g glycine, 3g GABA, 600mg ashwagandha, and a dual-release melatonin system.

Caffeine anhydrous delivers 350mg of this method’s ~500mg whole caffeine load, working by means of a well-established main mechanism: aggressive antagonism at adenosine A1 and A2A receptors.[20] These receptors act because the mind’s inhibitory checkpoints, suppressing arousal and dampening dopaminergic exercise beneath baseline situations. Blocking them disinhibits alertness circuitry, supporting documented enhancements in consideration, response time, and sustained vigilance.[21][22]

Bodily efficiency advantages observe. Meta-analyses verify caffeine considerably improves muscle power and endurance in comparison with placebo.[23][24] The ISSN’s place stand notes cardio endurance reveals probably the most constant and largest beneficial properties, and places the efficient ergogenic window at 3 to 6mg per kg physique weight.[25] At 350mg anhydrous, most customers sit squarely in that vary, with Infinergy’s contribution pushing the overall to ~500mg. That mixed load is solidly within the high-stim tier, which is exactly why Apollon’s half-serving suggestion is not a suggestion.

Caffeine consumed as early as six hours earlier than bedtime can meaningfully disrupt sleep at excessive doses,[26] making the product’s morning-to-early-afternoon cutoff crucial, not merely cautionary.

Infinergy™ Di-Caffeine Malate – 200mg (yields ~150mg of ~500mg whole caffeine)

Infinergy™ is branded di-caffeine malate, which contributes the remaining ~150mg of caffeine to Extra time’s whole load. The compound ionically bonds two caffeine molecules to malic acid, and in response to its producer, that ionic bond slows caffeine’s breakdown in comparison with the anhydrous type, extending the stimulant curve somewhat than including a second sharp spike.

Apollon Diet is again with CreaSmash — the primary complement that includes CreaSol SSAT! Analysis reveals 28% larger power beneficial properties and 51% higher endurance vs creatine alone. For those who’re critical about your coaching, this may very well be the creatine improve you have been ready for.

The malic acid element is a Krebs cycle intermediate that will help mobile vitality manufacturing, however we usually see much more malic acid in powdered dietary supplements than what could be right here. No impartial scientific trials on di-caffeine malate particularly exist, however the mechanism pairs logically with Extra time’s fast-onset anhydrous base.

CognatiQ® – 100mg

CognatiQ® is a complete espresso fruit focus standardized to 40% chlorogenic acids, sourced from the espresso cherry’s husk and pulp that standard bean processing discards. That distinction issues: the intact fruit’s polyphenol profile drives a BDNF elevation response that common espresso and caffeine-only extracts do not replicate in scientific testing.

BDNF (brain-derived neurotrophic issue) binds to TrkB receptors to help synaptic plasticity, neurogenesis, and upkeep of established neural networks. A single 100mg dose elevated plasma BDNF by 143% versus baseline in an acute pilot research,[27] and a bigger within-subject crossover (n=20) recorded 91% at 60 minutes, considerably above each placebo and freshly brewed espresso.[28] A separate crossover fMRI/MRS pilot discovered complete espresso cherry extract elevated BDNF, lowered response time, and enhanced anterior cingulate connectivity in decision-making and a spotlight networks.[29]

At 100mg, CognatiQ provides neuroplasticity help that enhances the quicker monoamine results of the PEA stack and caffeine.

SalidroPure® – 60mg

SalidroPure® is NNB Diet’s precision-fermented salidroside, the principal bioactive of Rhodiola rosea, produced as a nature-identical compound through fermentation somewhat than harvest from the now CITES-protected plant. The 60mg dose matches the precise protocol from the primary human RCT on pure biosynthetic salidroside.

Most collagen dietary supplements cease at one ingredient. Apollon Diet Collagen stacks 5 round a 15g marine base, masking exogenous provide, endogenous manufacturing, enzymatic safety, and joint help in a single scoop.

In that 2024 double-blind trial in 50 wholesome lively adults, 60mg/day for 16 days improved oxygen utilization throughout high-intensity intermittent train and blunted post-exercise myoglobin elevation, a marker of exercise-induced muscle harm.[30] The placebo group noticed declining efficiency and rising fatigue-inertia scores. The salidroside group maintained each.

The mechanism facilities on AMPK activation, which helps mitochondrial operate and nitric oxide manufacturing through the AMPK/PI3K/Akt/eNOS pathway.[30] A 2026 research utilizing SPR and CETSA validation additional recognized DRD2 (the dopamine D2 receptor) as a direct binding goal of salidroside and its in vivo metabolite tyrosol, with downstream ERK phosphorylation confirmed in neuronal cells.[31] That DRD2 exercise provides a receptor-level dopaminergic angle that enhances the release-side mechanisms driving the dual-PEA stack above.

It is a feel-good ingredient surrounded with extra of the identical, all hitting from totally different angles.

Vinpocetine (Voacanga Africana)(Seed) – 20mg

Vinpocetine is an artificial alkaloid derived from apovincamine, right here sourced from Voacanga africana seed somewhat than the standard periwinkle plant. A number of mechanisms account for its results on cerebral operate: selective inhibition of Ca²⁺/calmodulin-dependent cGMP-phosphodiesterase raises intracellular cGMP in vascular easy muscle, lowering cerebral vascular resistance and supporting wholesome cerebral blood circulate.[32] Vinpocetine additionally blocks voltage-gated Na⁺ channels with efficiency akin to phenytoin in rat cortical neurons.[33] A 3rd pathway targets NF-κB through direct IKK inhibition, supporting a wholesome inflammatory response by means of a mechanism impartial of PDE blockade.[34]

Apollon Diet The Specialist delivers 26 clinically-dosed components for complete organ help. 500mg TUDCA, 1200mg NAC, 1000mg bergamot, plus nutritional vitamins and minerals in 10 capsules day by day. Pharmaceutical-grade organ safety constructed for critical athletes.

In wholesome volunteers, 40mg vinpocetine improved reminiscence on the Sternberg scanning process.[35] A 16-week double-blind trial discovered 30mg/day improved world scientific impression and cognitive efficiency scores versus placebo.[36] At 20mg, Extra time’s dose sits on the decrease finish of clinically studied ranges — oral bioavailability will increase 60 to 100% when taken with meals versus a fasted state, making timing right here a bit extra essential.[37]

Inside this method, vinpocetine’s cerebral blood circulate help pairs naturally with the cholinergic stack, the place GPCgold™ and Huperzine A canopy acetylcholine from provide and degradation angles. Vinpocetine additionally inhibits adenosine reuptake,[32] including a complementary dimension to caffeine’s A1/A2A receptor antagonism already in play.

Rauwolscine 90% (Alpha Yohimbe) – 1.5mg

Now it is time to up the depth much more!

Rauwolscine, often known as alpha-yohimbine, is a stereoisomer of yohimbine however with totally different receptor selectivity. The place yohimbine retains reasonable exercise at each α1 and α2 adrenergic receptors, rauwolscine is greater than 50 occasions much less potent at α1, making it the extra selective α2-adrenergic antagonist of the 2.[38]

That selectivity issues quite a bit: blocking presynaptic α2 autoreceptors removes the unfavourable suggestions on norepinephrine launch, successfully turning up sympathetic tone. Postjunctional α2 blockade on adipocytes concurrently lifts the antilipolytic brake, permitting norepinephrine to drive β-adrenergic-mediated lipolysis extra freely. Analysis on oral α2 antagonism discovered elevated plasma free fatty acids and glycerol beneath fasted situations, an impact strengthened throughout train and totally suppressed after a meal.[39] Direct animal knowledge with rauwolscine additionally discovered lowered meals consumption.[40]

At 1.5mg, it will positively be felt however is a large-yet-supporting dose, not the lead driver. Its most related contribution in Extra time’s context could also be norepinephrine amplification, which pairs with L-Tyrosine’s precursor provide and the PEA stack’s monoamine launch to bolster the alertness facet of this method. Particular person response to α2 antagonists varies significantly.[41] That is another excuse to start out at 4 capsules.

Huperzine A 1% (Yielding 400 mcg Huperzine A) – 40mg

Huperzine A is a reversible acetylcholinesterase (AChE) inhibitor derived from the membership moss Huperzia serrata. By blocking AChE, it slows acetylcholine (ACh) clearance at cholinergic synapses, elevating availability in areas together with the prefrontal cortex and hippocampus.[42] In comparison with associated compounds, Huperzine A reveals roughly 900-fold selectivity for AChE over butyrylcholinesterase, narrowing its motion to the supposed pathway.[43][44] Oral dosing additionally produces longer-lasting AChE inhibition than comparable brokers at equal molar quantities.[45]

Rat microdialysis knowledge present that the ACh elevation from Huperzine A coincided with considerably elevated dopamine launch in each the medial prefrontal cortex and hippocampus, circuits concerned in working reminiscence and motivational drive.[45] That dopaminergic angle matches naturally alongside the dual-PEA stack already driving monoamine exercise upstream.

At 400mcg lively (40mg of 1% extract), the dose aligns with quantities utilized in placebo-controlled trials reporting enhancements in reminiscence quotient and cognitive take a look at scores.[43] That is additionally a a lot bigger dose than we usually see (it is normally within the 50-200mcg vary). Paired with 1200mg GPCgold™, the 2 elements help ACh operate from complementary angles: Alpha-GPC provides the precursor whereas Huperzine A slows its breakdown.

Robert “Robik” Samborsky, founding father of Apollon Diet and proprietor of the legendary Apollon Health club in Edison, NJ, shares his full origin story from Soviet-era Ukraine by means of Muay Thai title fights in Thailand to constructing some of the trusted hardcore complement manufacturers within the trade on Episode #211 of the PricePlow Podcast.